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The reciprocal mutation (Gln to Glu) on MhTyrA p reduced PDH activity while gaining ADH activity (Figure 4, Table 1), further supporting that the corresponding 222 position in microbial TyrA enzymes is also important for their substrate specificity
Data sources and literature searches A systematic literature search was conducted in the PubMed, Embase, and Cochrane databases using Medical Subject Headings terms and text keywords through April 2023 (eTable 1 in the Supplement)
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SS-31 (Elamipretide) SS-31 is a mitochondria-targeting peptide designed to support mitochondrial membrane integrity and energy production
ARG-BPC-157 is relevant when additional L-arginine delivery is experimentally desired or when enhanced stability at ambient conditions is a research requirement
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